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Inflammation & Immunology: Treatment at the Molecular Level 
Inflammation is a biological response to potential danger or damage to organs in our bodies. But with autoimmune diseases such as alopecia areata, rheumatoid arthritis, ulcerative colitis and many others, our own immune system becomes dysregulated and turns against our organs.1

These conditions may be painful and debilitating and can take an immense toll on people’s quality of life.

Our scientists are focused on three specific areas: rheumatology, gastroenterology, and medical dermatology. Our innovation in the short term is to enable patients to thrive in remission through new immunosuppressives, and in the future improve our understanding of how to promote the restoration of the immune system and tissue health.
Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a chronic, systemic, autoimmune disease that causes pain, inflammation, and swelling in the joints. This joint disease develops when a malfunctioning immune system attacks healthy joint tissues. Although there is no cure for rheumatoid arthritis, early treatment can put the disease into remission.2
Atopic Dermatitis
Eczema, also known as Atopic Dermatitis, is a chronic inflammatory skin condition that causes red, dry, and intensely itchy patches on the skin3. While it often begins in childhood, Atopic Dermatitis can persist into adulthood and become a lifelong condition.4

Discover helpful tips, understand treatment options and assess your eczema condition. Visit LivingWithEczema.sg and take the first step towards healthier skin health and a better quality of life.
Alopecia Areata
Alopecia Areata is an unpredictable, non-scarring hair loss condition that affects about 2% of the global population, with its prevalence continuing to rise.5,6 The most common form is patchy hair loss on the scalp, which often resolves on its own, but in some cases, it can progress to more severe forms like Alopecia Totalis or Universalis.5

Alopecia Areata is associated with multiple chronic conditions, including thyroid disorders, atopic conditions, cardiovascular risks, and mental health challenges.7 The emotional toll can be significant, with many patients experiencing anxiety, depression, and a reduced quality of life similar to those with other chronic skin conditions.8-11
 
Alopecia Areata affects more than appearance — it touches every part of daily life.  
Step into the shoes of Eric living with this condition, revealing the emotional and practical challenges he faces.
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References
  1. Pfizer UK website. Inflammation and Immunology. Last accessed: 19 August 2025. Retrieved from: https://www.pfizer.co.uk/science/our-therapy-areas/inflammation-and-immunology
  2. CDC website. Rheumatoid Arthritis: Symptoms, Treatment, Causes. Last accessed: 19 August 2025. Retrieved from: https://www.cdc.gov/arthritis/rheumatoid-arthritis/index.html
  3. Pfizer Australia website. Eczema: More Than Just a Skin Condition. Last accessed: 7 July 2025. Retrieved from: https://www.pfizer.com/news/articles/eczema_more_than_just_a_skin_condition  
  4. Living With Eczema Singapore website. What is Atopic Dermatitis. Last accessed: 19 August 2025. Retrieved from: https://www.livingwitheczema.sg/what-is-atopic-dermatitis
  5. Pratt, C. H., King, L. E., Jr, Messenger, A. G., Christiano, A. M., et al. (2017) Alopecia areata. Nature reviews. Disease primers, 3, 17011. Last accessed: 7 July 2025. Retrieved from:  https://doi.org/10.1038/nrdp.2017.11
  6. Lee HH, Gwillim E, Patel KR, et al. (2020) Epidemiology of alopecia areata, ophiasis, totalis, and universalis: A systematic review and meta-analysis J Am Acad Dermatol. 2020;82(3):675–682. Last accessed: 7 July 2025. Retrieved from: https://doi.org/10.1016/j.jaad.2019.08.032
  7. Lee S, Lee H, Lee CH, et al.(2019) Epidemiology and comorbidities of alopecia areata in Korea: A nationwide population-based study. J Am Acad Dermatol. 2019;80(2):466–477.e16. Last accessed: 7 July 2025. Retrieved from: https://doi.org/10.1016/j.jaad.2019.08.032
  8. Rodgers AR. (2018) Why Finding a Treatment for Alopecia Areata Is Important: A Multifaceted Perspective. J Investig Dermatol Symp Proc. 2018;19(1):S51–S53. Last accessed: 7 July 2025. Retrieved from: https://doi.org/10.1016/j.jisp.2017.10.008  
  9. Davey L, Clarke, V., & Jenkinson, E. (2019) Living with alopecia areata: an online qualitative survey study. The British journal of dermatology. 2019;180(6):1377–1389. Last accessed: 7 July 2025. Retrieved from:  https://doi.org/10.1111/bjd.17463
  10. Mesinkovska, N., King, B., Mirmirani, P., Ko, J., et al. (2020) Burden of Illness in Alopecia Areata: A Cross-Sectional Online Survey Study. The journal of investigative dermatology. Symposium proceedings, 20(1), S62–S68. Last accessed: 7 July 2025. Retrieved from: https://doi.org/10.1016/j.jisp.2020.05.007
  11. Liu, L. Y., King, B. A., & Craiglow, B. G. (2016) Health-related quality of life (HRQoL) among patients with alopecia areata (AA): A systematic review. Journal of the American Academy of Dermatology, 75(4), 806–812.e3. Last accessed: 7 July 2025. Retrieved from:  https://doi.org/10.1016/j.jaad.2016.04.035
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